“Large-scale brain models: a window to oscillatory interactions and distributed cognitive functions”.
During this INT/CONECT seminar, Prof. Jorge Mejias will present his research on “Large-scale brain models: a window to oscillatory interactions and distributed cognitive functions”
Abstract : Understanding how cognitive functions emerge from distributed cortical processing requires models that bridge local circuit dynamics and brain-wide interactions. In this talk, I will present data-constrained large-scale models of the macaque and mouse brains that integrate anatomical connectivity with biologically grounded local dynamics. I will first discuss how these models account for frequency-specific interactions across cortical areas, including the emergence of distinct communication channels and hierarchical patterns of directed influence. I will then illustrate how the same framework can be used to study cognitive functions such as working memory and perceptual decision-making, viewed as computations distributed across interacting cortical networks. Together, these studies show how large-scale circuit models can link structural connectivity, neural dynamics, and cognition across species.